Fresh analysis reveals that people who discontinue blockbuster slimming jabs like Mounjaro or Wegovy may regain shed pounds much more quickly than those who halt conventional diet and exercise programs.
Research printed in a leading medical journal points out that while overweight people frequently drop about a fifth of their total mass while undergoing treatment, the weight comes back at an average rate of nearly a kilo each month after stopping.
"People using these treatments need to be aware of the potential of quick rebound weight gain when the treatment concludes," stated researcher Dr. Susan Jebb.
That rate of regain suggests a reversion to starting mass in about 18 months.
Weighing Treatments
The research, which reviewed 37 of studies involving thousands of participants, compared the effects of the injectable medications with other pills.
The team point out that individuals who lose weight through lifestyle changes alone typically have a less rapid weight regain—perhaps 0.1 kg a month—once they finish.
Understanding the Quick Rebound
Experts suggest the mechanism of the jabs is key to understanding the accelerated rebound.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Sustained high doses of the hormone concentrations several times higher than the body's typical production might result in the body to produce less of its own natural GLP-1, and could reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this medication leads to appetite is unsuppressed, making excessive eating much more probable."
A Chronic Disease?
The NHS advise the injections for people with obesity-related medical conditions, alongside prescribed lifestyle changes.
Professionals contend that, considering the likelihood of relapse, the treatment might need to be ongoing.
This perspective is echoed by drug manufacturers, who say that the findings "underscore the chronic character of excess weight," similar to managing conditions like hypertension.
User Accounts
Individuals who have come off the jabs explain a sudden return of cravings.
"I experienced a switch activating and I was suddenly ravenous," recalled one woman.
The struggle is compounded if users have not adopted permanent lifestyle or habit modifications during treatment.
Significant Adoption
Survey data indicate that a significant number of people in the UK have tried these injections in the last 12 months, with desire being substantial.
- Use is greater among women compared to males.
- The 40s and 50s age group shows the greatest level of interest.
- Many access the medications through private healthcare rather than public health services.
Ultimately, researchers caution that while the jabs are powerful agents for shedding pounds, they are not a magic fix and lasting health benefits hinges on combined lifestyle changes.
